Viral Induction of Central Nervous System Innate Immune Responses

Innate and Adaptive Immune Responses Microglia Initiate Central Nervous System

Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection.

OBJECTIVE The role of innate immunity in the pathogenesis of cryptococcal meningitis is unclear. We hypothesized that natural killer (NK) cell and monocyte responses show central nervous system (CNS) compartment-specific profiles, and are altered by antifungal therapy and combination antiretroviral therapy (cART) during cryptococcal meningitis/HIV coinfection. DESIGN Substudy of a prospective...

Central Nervous System Infection Responses and Bacterial Clearance during Th1 and Th17 Cells Regulate Innate Immune

Immune response induction in the central nervous system.

The primary function of the immune response is protection of the host against infection with pathogens, including viruses. Since viruses can infect any tissue of the body, including the central nervous system (CNS), it is logical that cells of the immune system should equally have access to all tissues. Nevertheless, the brain and spinal cord are noted for their lack of immune presence. Relativ...

Innate immunity in the central nervous system.

Immune responses in the CNS are common, despite its perception as a site of immune privilege. These responses can be mediated by resident microglia and astrocytes, which are innate immune cells without direct counterparts in the periphery. Furthermore, CNS immune reactions often take place in virtual isolation from the innate/adaptive immune interplay that characterizes peripheral immunity. How...